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2018

Yasutomo K. Dysregulation of immunoproteasomes in autoinflammatory syndromes. Int Immunol (2018) in press

Tsukumo SI, Yasutomo K. Regulation of CD8+ T cells and anti-tumor immunity by Notch signaling (Review). Front Immunol 9:101 (2018)

2017

cell rep

Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K.
Slc3a2 mediates branched-chain amino-acid-dependent maintenance of regulatory T cells. 

Cell Rep 21:1824-1838 (2017)


pnas47 Saito Y, Respatika D, Komori S, Washio K, Nishimura T, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kaneko Y, Yui K, Yasutomo K, Nishigori C, Nojima Y, Matozaki T.
SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen. 
Proc Natl Acad Sci USA114:E10151-E10160 (2017)

J Immunol199

Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A, Yasutomo K. 
Notch balances Th17 and induced regulatory T cell functions in dendritic cells by regulating 
Aldh1a2 expression.
J Immunol 199:1989-1997 (2017)
同号のIn This Issueに選ばれる; DC Notch Knocks Down Th17 Differentiation. 


  Niki M, Nakajima K, Ishikawa D, Nishida J, Ishifune C, Tsukumo SI, Shimada M, Nagahiro S, Mitamura Y, Yasutomo K. MicroRNA-449a deficiency promotes colon carcinogenesis. Sci Rep 7:10696 (2017) 

Book

NotchSignaling ImmunityAndCancer  Yasutomo K. Notch Signaling: Immunity and Cancer. Springer (2017)

2016

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K, Yasutomo K. Survival of mature T cells depends on signaling through HOIP. Sci Rep  6:36135 (2016)

Furukawa T, Ishifune C, Tuskumo SI, Hozumi K, Maekawa Y, Matsui N, Kaji R, Yasutomo K.
 
Transmission of survival signals through Delta-like 1 on activated CD4+ T cells. Sci Rep 6:33692 (2016)

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signaling. Nat Commun 7:12597 (2016)

Arimochi H, Sasaki Y, Kitamura A, Yasutomo K.
Differentiation of preadipocytes and mature adipocytes requires PSMB8. Sci Rep
6: 26791 (2016)

2015

NatMed21 Maekawa Y, Ishifune C, Tsukumo SI, Hozumi K, Yagita H, Yasutomo K.
Notch controls the survival of memory CD4
+ T cells by regulating glucose uptake. 
Nat Med 21:55-61 (2015) 

News & Views: Notch signaling maintains T cell memories (by Miller AM & Schoenberger SP). Nat Med 21:16–18 (2015)
ライフサイエンス新着論文レビューへのリンク
http://first.lifesciencedb.jp/archives/9670


jlb98 Oh SJ, Ahn S, Jin YH, Ishifune C, Kim JH, Yasutomo K, and Chung DH.
Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells. 

J Leukoc Biol 98:781-789 (2015)

Kurihara T, Arimochi H, Bhuyan ZA, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Maekawa Y, Yasutomo K. CD98 heavy chain Is a potent positive regulator of CD4+ T cell proliferation and interferon-γ production in vivo. PLoS One 10:e0139692 (2015)


 

2014

jem211

Kitamura A, Sasaki Y, Abe T, Kano H, Yasutomo K.
An inherited mutation in NLRC4 causes autoinflammation in human and mice
. 
J Exp Med 211:2385-2396 (2014)

Insight: Too much of a good thing: NLRC4 and autoinflammation (by Anderson MS)  J Exp Med 211:2329 (2014)

SciBX 7(47); doi:10.1038/scibx.2014.1393
Mutant NRL family CARD domain containing 4 (NLRC4) as a marker of familial cold autoinflammatory syndrome (FCAS)


pnas111 Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K. Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling. 
Proc Natl Acad Sci USA 111:5986-5991 (2014)

Bhuyan ZA, Asanoma M, Iwata A, Ishifune C, Maekawa Y, Shimada M, Yasutomo K. Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells. PLoS One 9:e89266 (2014)


bbrc444 Bhuyan ZA, Arimochi H, Nishida J, Kataoka K, Kurihara T, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Yasutomo K.
CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4+ T cells.
 

Biochem Biophys Res Commun.444:628-33 (2014)

2013

Nakajima K, Maekawa Y, Kataoka K, Ishifune C, Nishida J, Arimochi H, Kitamura A, Yoshimoto T, Tomita S, Nagahiro S, Yasutomo K. The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+cells. Nat Commun 4:2112 (2013)


International Journal of Hematology98 Sawada A, Ohga S, Ishii E, Inoue M, Okada K, Inagaki J, Goto H, Suzuki N, Koike K, Atsuta Y, Suzuki R, Yabe H, Kawa K, Kato K, Yasutomo K. Feasibility of reduced-intensity conditioning followed by unrelated cord blood transplantation for primary hemophagocytic lymphohistiocytosis: a nationwide retrospective analysis in Japan. 
Int J Hematol 98:223-30 (2013)

 


Wakimoto S, Nakayama-Imaohji H, Ichimura M, Morita H, Hirakawa H, Hayashi T, Yasutomo K, Kuwahara T. PhoB regulates the survival of Bacteroides fragilis in peritoneal abscesses. PLoS One 8: e53829 (2013)

2012

J Immunol188 Lian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, Yasutomo K.
Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.

J Immunol 188:2227-34 (2012)

1 s2 1

Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoko K, Chiba S, Shimada M, Yasutomo K.
Notch2 regulates the development of marginal zone B cells through Fos. 

Biochem Biophys Res Commun 418:701-707 (2012)


 ajh87

Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S.
Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis.

Am J Hematol 87:637-9 (2012)


Digestive Diseases and Sciences57 Nemoto H, Kataoka K, Ishikawa H, Ikata K, Arimochi H, Iwasaki T, Ohnishi Y, Kuwahara T, Yasutomo K.
Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis. 

Dig Dis Sci 57:2955-64 (2012)

Mol Cancer Ther11 Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y.
Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity. 

Mol Cancer Ther 11:2578-87 (2012)

2011

 121 10 cover Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K.
A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans. 

J Clin Invest 121:4150–4160 (2011)

In this issue
Mutation-mechanism-disease
J Clin Invest 121:3765 (2011)


 5.cover source Xu M, Morishima N, Mizoguchi I, Chiba Y, Fujita K, Kuroda M, Iwakura Y, Cua DJ, Yasutomo K, Mizuguchi J, Yoshimoto T.
Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production.

Eur J Immunol 41:2828-2839 (2011)

123 Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW.
Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells. 

Int Arch Allergy Immunol 157:65-72 (2011)

m cover Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T.
The Lifestyle of the Segmented Filamentous Bacterium: A Non-Culturable Gut-Associated Immunostimulating Microbe Inferred by Whole-Genome Sequencing. 

DNA Res 18:291-303 (2011)

eji Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, Yasutomo K.
Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.
Eur J Immunol 41:1309-20 (2011) 

1 Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito T, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S. 
Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.

Blood 117:128-34 (2011)

2010

13 Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K.
Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor. 
Proc Natl Acad Sci USA 107:5943-5948 (2010)

9 Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K.
Notch2 signaling is required for potent anti-tumor immunity in vivo. 

J Immunol 184:4673-8 (2010)

2 Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S.
Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. 

Ann Rheum Dis 69:368-73 (2010)

2009

1 s2 Erdenebayar N, Maekawa Y, Nishida J, Kitamura A, Yasutomo K.
Protein tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling. 

Biochem Biophys Res Commun 18;390:489-93 (2009)

5 Okamoto M, Matsuda H, Lucas JL, Domenico J, Yasutomo K, Takeda K, Gelfand EW.
Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. 

J Immunol 183:2995-3003 (2009)

8 Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda SI, Nikawa T. 
Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading.
 
Mol Cell Biol 29:4798-811(2009)

10 Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-15. 

J Immunol 182:6168-78 (2009)

6 Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.  
Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K. 
J Immunol 182:3566-3572 (2009)

2008

ni v9 n10 Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K.
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. 
 
Nat Immunol 9:1140-7 (2008)

22.cover source Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S.
Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate. 

Proc Natl Acad Sci USA 105:7839-7844 (2008)

Commentary
Dedhia P, Kambayashi T, Pear WS. Notch2 paves the way to mast cells by Hes1 and Gata3.
Proc Natl Acad Sci USA 105: 7629-7630 (2008)


5 1 Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Yasutomo K, Dakhama A, Gelfand EW.
Essential role of Notch signaling in effector memory CD8+ T cell–mediated airway hyperresponsiveness and inflammation. 
 
J Exp Med 205:1087-97 (2008)

19 Kijima M, Yamaguchi T, Ishifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K.
Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.
 
Proc Natl Acad Sci USA 105: 7010-7015 (2008)

art Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S.
Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. 
 
Arthritis Rheum. 58:1940-46 (2008)

4.cover source Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K. 
Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells. 

J Immunol 180: 2496-2503 (2008)

1 s2 1 Li S, Kishihara K, Akashi N, Hara H, Yoshikai Y, Maekawa Y, Yasutomo K. 
Vdelta1+ T cells are crucial for repertoire formation of gammadelta T cells in the lung.

Biochem Biophys Res Commun. 365:246-51 (2008). 

2007

7 Tao K, Fujii M, Tsukumo S, Maekawa Y, Kishihara K, Kimoto Y, Horiuchi T, Hisaeda H, Akira S, Kagami S, Yasutomo K.
Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.
 
Ann Rheum Dis. 66:905-9 (2007)

1 s2 2 Kose H,Sakai T, Tsukumo SI, Wei K, Yamada T, Yasutomo K, Matsumoto K.
Maturational arrest of thymocyte development is caused by a deletion in receptor-like protein tyrosine phosphatase kappa Gene in LEC rats. 
 
Genomics 89:673-7 (2007)

biof Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida M, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E.
Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation. 

Biofactors. 30:105-16 (2007).

2006

12 1.cover source Tsukumo SI, Hirose K, Maekawa Y, Kishihara K, Yasutomo K.
Lunatic Fringe controls T cell differentiation through modulating Notch signaling. 
 
J Immunol 177:8365-8371 (2006)

LargeRollover.00006676 200611000 00000 Ikemoto T, Yamaguchi T, Morine Y, Imura S, Soejima Y, Fujii M, Maekawa Y, Yasutomo K, Shimada M.
Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients. 

Pancreas 33:386-90 (2006)

2005

eji 1 Hisaeda H, Hamano S, Mitoma-Obata C, Tetsutani K, Imai T, Waldmann H, Himeno K, Yasutomo K.
Resistance to GITR signaling in antigen specific CD4+CD25+ regulatory T cells during Plasmodium yoelii infection. 

Eur J Immunol 35:3516-24 (2005)

12185 Minato Y and Yasutomo K.
Regulation of acquired immune system by Notch signaling (review). 

Int J Hematol 82:302-6 (2005)

2ff21abf44b19838 Hisaeda H, Yasutomo K, Himeno K.
Malaria: immune evasion by parasites (review).  

Int J Biochem Cell Biol. 37:700-6 (2005).

1 s2 3 Maekawa Y, Yasutomo K.
Antigen-driven T-cell repertoire selection (review).  

Crit Rev Immunol. 25:59-74 (2005).

2004

 homecover Hisaeda H, Maekawa Y, Iwakawa D, Okada H, Himeno K, Kishihara K, Tsukumo SI, Yasutomo K.Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T-cells. 
Nat Med 10:29-30 (2004)

12 Tsukumo SI, Yasutomo K.
Notch governing mature T-cell differentiation (Review). 
 
J Immunol 173: 7109-7113 (2004).


Tsukumo SI, Yasutomo K. DNase1 in pathogenesis of systemic lupus erythematosus (Review). Clin Immunol 113:14-18 (2004)

art 1 Hayashi Y, Ishimaru N, Arakaki R, Tsukumo SI, Fukui H, Kishihara K, Shiota H, Yasutomo K#, Hayashi Y (# C. author).
Effective treatment of Sjogren's syndrome mouse model by eye drop administration with anti-CD4 monoclonal antibody. 

Arthritis Rheum 50:2903-2910 (2004)

9 1 Hayashi Y, Tsukumo SI, Shiota H, Kishihara K, Yasutomo K.
Antigen specific T-cell repertoire modification of CD4+CD25+ regulatory T-cells.

J Immunol 172:5240-5248 (2004)

 

2003

cov150h Maekawa Y, Tsukumo SI, Chiba S, Hirai H, Hayashi Y, Okada H, Kishihara K, Yasutomo K. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T-cells. 
Immunity 19:549-59 (2003).

SmallThumb.00007890 201804000 00000 Maekawa Y, Tsukumo SI, Okada H, Kishihara K, Yasutomo K.
Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation. 

Transplantation. 76:415-20 (2003)

m1 cover Yasutomo K.
Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus (Review). 

Rheumatology 42:214-22 (2003)

2001以前の主要なもの

small 1 placeholder cover Maekawa Y, Yasutomo K.
Defective clearance of nucleosomes and systemic lupus erythematosus. 

Trends Immunol. 22:662-3 (2001)

ng v28 n4 Yasutomo K, Horiuchi T, Kagami S, Tsukamoto H, Hashimura C, Urushihara M, Kuroda Y. Mutation of DNASE1 in people with systemic lupus erythematosus. 
Nat Genet. 28:313-4 (2001)

ni v1 n4 Dorfman JR, Stefanova I, Yasutomo K, Germain RN.
CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. 

Nat Immunol 1:329-35 (2000)

6 1 Yasutomo K, Lucas B, Germain RN.
TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type. 

J Immunol. 165:3015-22 (2000)

41586 555 7696 Yasutomo K, Doyle C, Miele L, Fuchs C, Germain RN.
The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. 

Nature.404:506-10 (2000)

cov150h Lu FW, Yasutomo K, Goodman GB, McHeyzer-Williams LJ, McHeyzer-Williams MG, Germain RN, Ashwell JD.
Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire. 

Immunity. 12:183-92 (2000)

cov150 1h Lucas B, Stefanova I, Yasutomo K, Dautigny N, Germain RN.
Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. 

Immunity. 10:367-76 (1999)

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