2019

Ishifune C, Tsukumo SI, Maekawa Y, Hozumi K, Chung DH, Motozono C, Yamasaki S, Nakano H, Yasutomo K. Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.
PLoS Biol 17(5):e3000262 (2019)

Yasutomo K. Dysregulation of immunoproteasomes in autoinflammatory syndromes.
Int Immunol 31:631-637 (2019)

Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, Yasutomo K. A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.
J Exp Med (2019) in press

2018

Tsukumo SI, Yasutomo K. Regulation of CD8+ T cells and anti-tumor immunity by Notch signaling (Review). Front Immunol 9:101 (2018)

2017

Ikeda K, Kinoshita M, Kayama H, Nagamori S, Kongpracha P, Umemoto E, Okumura R, Kurakawa T, Murakami M, Mikami N, Shintani Y, Ueno S, Andou A, Ito M, Tsumura H, Yasutomo K, Ozono K, Takashima S, Sakaguchi S, Kanai Y, Takeda K. Slc3a2 mediates branched-chain amino-acid-dependent maintenance of regulatory T cells.  Cell Rep 21:1824-1838 (2017)

Saito Y, Respatika D, Komori S, Washio K, Nishimura T, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kaneko Y, Yui K, Yasutomo K, Nishigori C, Nojima Y, Matozaki T. SIRPα+ dendritic cells regulate homeostasis of fibroblastic reticular cells via TNF receptor ligands in the adult spleen.  Proc Natl Acad Sci USA114:E10151-E10160 (2017)

Zaman TS, Arimochi H, Maruyama S, Ishifune C, Tsukumo SI, Kitamura A, Yasutomo K.  Notch balances Th17 and induced regulatory T cell functions in dendritic cells by regulating Aldh1a2 expression. J Immunol 199:1989-1997 (2017) 同号のIn This Issueに選ばれる; DC Notch Knocks Down Th17 Differentiation.

Book

Yasutomo K. Notch Signaling: Immunity and Cancer. Springer (2017)

2016

Okamura K, Kitamura A, Sasaki Y, Chung DH, Kagami S, Iwai K, Yasutomo K. Survival of mature T cells depends on signaling through HOIP. Sci Rep  6:36135 (2016)

Furukawa T, Ishifune C, Tuskumo SI, Hozumi K, Maekawa Y, Matsui N, Kaji R, Yasutomo K. Transmission of survival signals through Delta-like 1 on activated CD4+ T cells. Sci Rep 6:33692 (2016)

Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signaling. Nat Commun 7:12597 (2016)

Arimochi H, Sasaki Y, Kitamura A, Yasutomo K. Differentiation of preadipocytes and mature adipocytes requires PSMB8. Sci Rep 6: 26791 (2016)

2015

Maekawa Y, Ishifune C, Tsukumo SI, Hozumi K, Yagita H, Yasutomo K. Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.  Nat Med 21:55-61 (2015)

News & Views: Notch signaling maintains T cell memories (by Miller AM & Schoenberger SP). Nat Med 21:16–18 (2015)
ライフサイエンス新着論文レビューへのリンク
http://first.lifesciencedb.jp/archives/9670

Oh SJ, Ahn S, Jin YH, Ishifune C, Kim JH, Yasutomo K, and Chung DH. Notch 1 and Notch 2 synergistically regulate the differentiation and function of invariant NKT cells.  J Leukoc Biol 98:781-789 (2015)

Kurihara T, Arimochi H, Bhuyan ZA, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Maekawa Y, Yasutomo K. CD98 heavy chain Is a potent positive regulator of CD4+ T cell proliferation and interferon-γ production in vivo. PLoS One 10:e0139692 (2015)

2014

Kitamura A, Sasaki Y, Abe T, Kano H, Yasutomo K. An inherited mutation in NLRC4 causes autoinflammation in human and mice.  J Exp Med 211:2385-2396 (2014)

Insight: Too much of a good thing: NLRC4 and autoinflammation (by Anderson MS)  J Exp Med 211:2329 (2014)

SciBX 7(47); doi:10.1038/scibx.2014.1393
Mutant NRL family CARD domain containing 4 (NLRC4) as a marker of familial cold autoinflammatory syndrome (FCAS)

Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K. Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling.  Proc Natl Acad Sci USA 111:5986-5991 (2014)

Bhuyan ZA, Asanoma M, Iwata A, Ishifune C, Maekawa Y, Shimada M, Yasutomo K. Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells. PLoS One 9:e89266 (2014)

Bhuyan ZA, Arimochi H, Nishida J, Kataoka K, Kurihara T, Ishifune C, Tsumura H, Ito M, Ito Y, Kitamura A, Yasutomo K. CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4+ T cells.　 Biochem Biophys Res Commun.444:628-33 (2014)

2013

Nakajima K, Maekawa Y, Kataoka K, Ishifune C, Nishida J, Arimochi H, Kitamura A, Yoshimoto T, Tomita S, Nagahiro S, Yasutomo K. The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+cells. Nat Commun 4:2112 (2013)

Sawada A, Ohga S, Ishii E, Inoue M, Okada K, Inagaki J, Goto H, Suzuki N, Koike K, Atsuta Y, Suzuki R, Yabe H, Kawa K, Kato K, Yasutomo K. Feasibility of reduced-intensity conditioning followed by unrelated cord blood transplantation for primary hemophagocytic lymphohistiocytosis: a nationwide retrospective analysis in Japan.  Int J Hematol 98:223-30 (2013)

Wakimoto S, Nakayama-Imaohji H, Ichimura M, Morita H, Hirakawa H, Hayashi T, Yasutomo K, Kuwahara T. PhoB regulates the survival of Bacteroides fragilis in peritoneal abscesses. PLoS One 8: e53829 (2013)

2012

Lian G, Arimochi H, Kitamura A, Nishida J, Li S, Kishihara K, Maekawa Y, Yasutomo K. Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice. J Immunol 188:2227-34 (2012)

Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoko K, Chiba S, Shimada M, Yasutomo K. Notch2 regulates the development of marginal zone B cells through Fos.  Biochem Biophys Res Commun 418:701-707 (2012)

Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S. Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis. Am J Hematol 87:637-9 (2012)

Nemoto H, Kataoka K, Ishikawa H, Ikata K, Arimochi H, Iwasaki T, Ohnishi Y, Kuwahara T, Yasutomo K. Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis.  Dig Dis Sci 57:2955-64 (2012)

Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y. Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity.  Mol Cancer Ther 11:2578-87 (2012)

2011

Kitamura A, Maekawa Y, Uehara H, Izumi K, Kawachi I, Nishizawa M, Toyoshima Y, Takahashi H, Standley DM, Tanaka K, Hamazaki J, Murata S, Obara K, Toyoshima I, Yasutomo K. A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans.  J Clin Invest 121:4150–4160 (2011)

In this issue
Mutation-mechanism-disease
J Clin Invest 121:3765 (2011)

Xu M, Morishima N, Mizoguchi I, Chiba Y, Fujita K, Kuroda M, Iwakura Y, Cua DJ, Yasutomo K, Mizuguchi J, Yoshimoto T. Regulation of the development of acute hepatitis by IL-23 through IL-22 and IL-17 production. Eur J Immunol 41:2828-2839 (2011)

Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW. Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells.  Int Arch Allergy Immunol 157:65-72 (2011)

Kuwahara T, Ogura Y, Oshima K, Kurokawa K, Ooka T, Hirakawa H, Itoh T, Nakayama-Imaohji H, Ichimura M, Itoh K, Ishifune C, Maekawa Y, Yasutomo K, Hattori M, Hayashi T. The Lifestyle of the Segmented Filamentous Bacterium: A Non-Culturable Gut-Associated Immunostimulating Microbe Inferred by Whole-Genome Sequencing.  DNA Res 18:291-303 (2011)

Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, Yasutomo K. Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus. Eur J Immunol 41:1309-20 (2011)

Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito T, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S.  Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine. Blood 117:128-34 (2011)

2010

Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K. Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.  Proc Natl Acad Sci USA 107:5943-5948 (2010)

Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K. Notch2 signaling is required for potent anti-tumor immunity in vivo.  J Immunol 184:4673-8 (2010)

Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, Nakamura Y, Yano K, Iikuni N, Tsukahara S, Kamatani N, Okamoto H, Kaneko H, Kawaguchi Y, Hara M, Toyama Y, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Yamanaka H, Momohara S. Association study of TRAF1-C5 polymorphisms with susceptibility to　rheumatoid arthritis and systemic lupus erythematosus in Japanese.  Ann Rheum Dis 69:368-73 (2010)

2009

Erdenebayar N, Maekawa Y, Nishida J, Kitamura A, Yasutomo K. Protein tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling.  Biochem Biophys Res Commun 18;390:489-93 (2009)

Okamoto M, Matsuda H, Lucas JL, Domenico J, Yasutomo K, Takeda K, Gelfand EW. Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.  J Immunol 183:2995-3003 (2009)

Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda SI, Nikawa T.  Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading.  Mol Cell Biol 29:4798-811(2009)

Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S. Notch activation induces the generation of functional natural killer cells from human cord blood CD34-positive cells devoid of interleukin-15.  J Immunol 182:6168-78 (2009)

Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.   Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K.  J Immunol 182:3566-3572 (2009)

2008

Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto M, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K. Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.   Nat Immunol 9:1140-7 (2008)

Sakata-Yanagimoto M, Nakagami-Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S. Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate.  Proc Natl Acad Sci USA 105:7839-7844 (2008)

Commentary
Dedhia P, Kambayashi T, Pear WS. Notch2 paves the way to mast cells by Hes1 and Gata3.
Proc Natl Acad Sci USA 105: 7629-7630 (2008)

Okamoto M, Takeda K, Joetham A, Ohnishi H, Matsuda H, Swasey CH, Yasutomo K, Dakhama A, Gelfand EW. Essential role of Notch signaling in effector memory CD8+ T cell–mediated airway hyperresponsiveness and inflammation.   J Exp Med 205:1087-97 (2008)

Kijima M, Yamaguchi T, Ishifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K. Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.  Proc Natl Acad Sci USA 105: 7010-7015 (2008)

Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, Nakamura Y, Toyama Y, Mochizuki T, Tsukahara S, Kawaguchi Y, Terai C, Hara M, Tomatsu T, Yamanaka H, Horiuchi T, Tao K, Yasutomo K, Hamada D, Yasui N, Inoue H, Itakura M, Okamoto H, Kamatani N, Momohara S. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese.   Arthritis Rheum. 58:1940-46 (2008)

Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K.  Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.  J Immunol 180: 2496-2503 (2008)

Li S, Kishihara K, Akashi N, Hara H, Yoshikai Y, Maekawa Y, Yasutomo K.  Vdelta1+ T cells are crucial for repertoire formation of gammadelta T cells in the lung. Biochem Biophys Res Commun. 365:246-51 (2008).

2007

Tao K, Fujii M, Tsukumo S, Maekawa Y, Kishihara K, Kimoto Y, Horiuchi T, Hisaeda H, Akira S, Kagami S, Yasutomo K. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population.  Ann Rheum Dis. 66:905-9 (2007)

Kose H,Sakai T, Tsukumo SI, Wei K, Yamada T, Yasutomo K, Matsumoto K. Maturational arrest of thymocyte development is caused by a deletion in receptor-like protein tyrosine phosphatase kappa Gene in LEC rats.   Genomics 89:673-7 (2007)

Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida M, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E. Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation.  Biofactors. 30:105-16 (2007).

2006

Tsukumo SI, Hirose K, Maekawa Y, Kishihara K, Yasutomo K. Lunatic Fringe controls T cell differentiation through modulating Notch signaling.   J Immunol 177:8365-8371 (2006)

Ikemoto T, Yamaguchi T, Morine Y, Imura S, Soejima Y, Fujii M, Maekawa Y, Yasutomo K, Shimada M. Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients.  Pancreas 33:386-90 (2006)

2005

Hisaeda H, Hamano S, Mitoma-Obata C, Tetsutani K, Imai T, Waldmann H, Himeno K, Yasutomo K. Resistance to GITR signaling in antigen specific CD4+CD25+ regulatory T cells during Plasmodium yoelii infection.  Eur J Immunol 35:3516-24 (2005)

Minato Y and Yasutomo K. Regulation of acquired immune system by Notch signaling (review).  Int J Hematol 82:302-6 (2005)

Hisaeda H, Yasutomo K, Himeno K. Malaria: immune evasion by parasites (review).   Int J Biochem Cell Biol. 37:700-6 (2005).

Maekawa Y, Yasutomo K. Antigen-driven T-cell repertoire selection (review).   Crit Rev Immunol. 25:59-74 (2005).

2004

Hisaeda H, Maekawa Y, Iwakawa D, Okada H, Himeno K, Kishihara K, Tsukumo SI, Yasutomo K.Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T-cells.  Nat Med 10:29-30 (2004)

Tsukumo SI, Yasutomo K. Notch governing mature T-cell differentiation (Review).   J Immunol 173: 7109-7113 (2004).

Tsukumo SI, Yasutomo K. DNase1 in pathogenesis of systemic lupus erythematosus (Review). Clin Immunol 113:14-18 (2004)

Hayashi Y, Ishimaru N, Arakaki R, Tsukumo SI, Fukui H, Kishihara K, Shiota H, Yasutomo K#, Hayashi Y (# C. author). Effective treatment of Sjogren's syndrome mouse model by eye drop administration with anti-CD4 monoclonal antibody.  Arthritis Rheum 50:2903-2910 (2004)

Hayashi Y, Tsukumo SI, Shiota H, Kishihara K, Yasutomo K. Antigen specific T-cell repertoire modification of CD4+CD25+ regulatory T-cells. J Immunol 172:5240-5248 (2004)

2003

Maekawa Y, Tsukumo SI, Chiba S, Hirai H, Hayashi Y, Okada H, Kishihara K, Yasutomo K. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T-cells.  Immunity 19:549-59 (2003).

Maekawa Y, Tsukumo SI, Okada H, Kishihara K, Yasutomo K. Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation.  Transplantation. 76:415-20 (2003)

Yasutomo K. Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus (Review).  Rheumatology 42:214-22 (2003)

2001以前の主要なもの

Maekawa Y, Yasutomo K. Defective clearance of nucleosomes and systemic lupus erythematosus.  Trends Immunol. 22:662-3 (2001)

Yasutomo K, Horiuchi T, Kagami S, Tsukamoto H, Hashimura C, Urushihara M, Kuroda Y. Mutation of DNASE1 in people with systemic lupus erythematosus.  Nat Genet. 28:313-4 (2001)

Dorfman JR, Stefanova I, Yasutomo K, Germain RN. CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling.  Nat Immunol　1:329-35 (2000)

Yasutomo K, Lucas B, Germain RN. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type.  J Immunol. 165:3015-22 (2000)

Yasutomo K, Doyle C, Miele L, Fuchs C, Germain RN. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.  Nature.404:506-10 (2000)

Lu FW, Yasutomo K, Goodman GB, McHeyzer-Williams LJ, McHeyzer-Williams MG, Germain RN, Ashwell JD. Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to holes in the T cell repertoire.  Immunity. 12:183-92 (2000)

Lucas B, Stefanova I, Yasutomo K, Dautigny N, Germain RN. Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire.  Immunity. 10:367-76 (1999)